Publications
J.J. Mayfield, J. Bogomolovas, M.R. Abraham, K. Sullivan, Y. Seo, F. Sheikh*, M. Scheinman* (2023) Recurrent Myocarditis in Patients With Desmosomal Pathogenic Variants: Is Self Antigen Presentation The Link? J Am Coll Cardiol EP (in press) *co-corresponding authors
J. Zhang, E.J. Gutierrez-Lara, Y. Liang and F. Sheikh (2022) Functions Beyond the Editor’s I in Regulating Cardiac Innate Immunity and Heart Failure. Circ Res 131: 598-600. PMID: 36108055
D.M. Calcagno, N. Taghdiri, V.K. Ninh, J.M. Mesfin, A. Toomu, R. Sehgal, J. Lee, Y. Liang, J.M. Duran, E. Adler, K.L. Christman, K. Zhang, F. Sheikh, Z. Fu and K.R. King (2022) Single cell and spatial transcriptomics of the infarcted heart define the dynamic onset of the border zone in response to mechanical destabilization. Nat Cardiovas Res 1:1039-1055.
C. Schinner, L. Xu, H. Franz, A. Zimmermann, M.T. Wanuske, M. Rathod, P. Hanns, F. Geier, P. Pelczar, Y. Liang, V. Lorenz, C. Studle, P.I. Maly, S. Kauferstein, B.M. Beckmann, F. Sheikh, G.M. Kuster, V. Spindler (2022) Defective Desmosomal Adhesion Causes Arrhythmogenic Cardiomyopathy by involving an Integrin-aVb6/TGF-b Signaling Cascade. Circulation 146(21):1610-1626. PMID: 36268721
R.J. van der Pijl, A.A. Domenighetti, F. Sheikh, E. Ehler, C.A.C Ottenheijm and S. Lange (2021) The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles. Biophysical Reviews 13(5): 653-677. PMID: 34745373
J. Zhang, Y. Liang, W.H. Bradford and F. Sheikh (2021) Desmosomes: emerging pathways and non-canonical functions in cardiac arrhythmias and disease. Biophysical Reviews 13(5): 697–706. PMID: 34765046.
Y. Liang, R.C. Lyon, J. Pellman, W.H. Bradford, S. Lange, J. Bogomolovas, N.D. Dalton, Y. Gu, M. Bobar, M.H. Lee, T. Iwakuma, V. Nigam, A. Asimaki, M. Scheinman, K.L. Peterson and F. Sheikh (2021) Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Clin Invest 131(11):e137689. PMID: 33857019.
M. Pinsach-Abuin, B. Del Olmo, A. Perez-Agustin, J. Mates, C. Allegue, A. Iglesias, Q. Ma, D. Merkurjev, S. Konovalov, J. Zhang, F. Sheikh, A. Telenti, J. Brugada, R. Brugada, M. Gymrek, J. di Lulio, I. Garcia-Bassets and S. Pagan (2021) Analysis of Brugada syndrome loci reveals that fine-mapping clustered GWAS hits enhances the annotation of disease-relevant variants. Cell Reports 2(4): 100250. PMID: 33948580.
W. Ying, K. Tang, E. Avolio, J.M. Schilling, T. Pasqua, M.A. Liu, H. Cheng, H. Gao, J. Zhang, S. Mahata, M.S. Ko, G. Bandyopadhyay, S. Das, D.M. Roth, D. Sahoo, N.J.G. Webster, F. Sheikh, G. Ghosh, H.H. Patel, P. Ghosh, G. van den Bogaart and S.K. Mahata. Immunosuppression of Macrophages Underlies the Cardioprotective Effects of CST (Catestatin) (2021) Hypertension 77(5): 1670-1682. PMID: 33826401.
Y. Liang and F. Sheikh (2020) Zippering Up A Role for ZO-1 In Cardiac Conduction Disease. Circ Res 127(2): 298-300. PMID: 32614716
C.Y. Kam, A.D. Dubash, E. Magistrati, S. Polo, K.J.F. Satchell, F. Sheikh, P.D. Lampe and K.J. Green (2018)
Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43. J Cell Biol 217(9):3219-3235. PMID: 29959233.
Y. Liang, W.H. Bradford, J. Zhang and F. Sheikh (2018). Four and a half LIM domain protein signaling and
cardiomyopathy. Biophys Rev 10(4):1073-1085. PMID: 29926425.
K. Musunuru, P. Arora, J.P. Cooke, J.F. Ferguson, R.E. Hershberger, K.T. Hickey, J.M. Lee, J.A.C. Lima, J. Loscalzo,
N.L. Pereira, M.W. Russell, S.H. Shah, F. Sheikh, T.J. Wang and C.A. MacRae (2018) Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine: A Scientific Statement From the American Heart Association. Circ Genom Precis Med 11(6):e000046. PMID: 29844141.
J. Krysiak, A. Unger, L. Beckendorf, N. Hamdani, M. von Frieling-Salewsky, M.M. Redfield, C.G. Dos Remedios, F.
Sheikh, U. Gergs, P. Boknik and W.A. Linke (2018) Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes. Nat Commun 9(1):262. PMID: 29343782.
K. Musunuru, F. Sheikh, R.M. Gupta, S.R. Houser, K.O. Maher, D.J. Milan, A. Terzic and J.C. Wu (2018) Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling and Precision Medicine: A Scientific Statement From the American Heart Association. Circ Genom Precis Med 11(1):e000043. PMID: 29874173.
W.H. Bradford, J.H. Omens and F. Sheikh (2017) Vinculin at the Heart of Aging. Annals Transl Med 5: 62. PMID:28251141.
J. Pellman, J. Zhang and F. Sheikh (2016) Myocyte-Fibroblast Communication in Cardiac Fibrosis and Arrhythmias. J Mol Cell Cardiol (special issue on Fibrosis and Myocardial Remodeling) 94: 22-31. PMID: 26996756.
Y. Liang and F. Sheikh (2016) Scaffold Proteins Regulating Extracellular Regulated Kinase Function in Cardiac
Hypertrophy and Disease. Front Pharmacol 7: 37. PMID: 26973524
F. Zanella and F. Sheikh (2016) Generation and characterization of cardiac cells. In: Nagy A, Turksen K (eds) Patient-
specific induced pluripotent stem cell models. Methods Mol Biol 1353:147-162. PMID: 25520292
V. Mezzano, Y. Liang, A.T. Wright, R.C. Lyon, E. Pfeiffer, M.Y. Song, Y. Gu, N.D. Dalton, M. Scheinman, K.L.
Peterson, S.M. Evans, S. Fowler, M. Cerrone, A.D. McCulloch and F. Sheikh (2016) Desmosomal Junctions Are Necessary for Adult Sinus Node Function. Cardiovasc Res 111: 274-286. PMID: 27097650 *Selected as Editor’s Choice (Editorial: Mangoni (2016) Desmosomes and sinoatrial dysfunction. Cardiovasc Res 111:167-168.)
X. Ma, X. Qu, W. Zhu, Y.S. Li, S. Yuan, H. Zhang, J. Liu, P. Wang, C.S. Lai, F. Zanella, G.S. Feng, F. Sheikh, S.
Chien and S. Chen (2016) Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D
bioprinting. Proc Natl Acad Sci USA 113:2206-2211. PMID: 26858399
F. Zanella and F. Sheikh (2016) Working with Stem Cells - Quick and easy methodologies and applications:
Differentiation of hiPSC-derived Cardiomyocytes. Springer Book Chapter.
R.C. Lyon and F. Sheikh (2015) Cardiovascular Pathology. Heart Failure: Heart failure-related alterations in cellular
function and biochemical pathways. Elsevier. 4th edition.
F. Sheikh§, R.C. Lyon and J. Chen (2015) Functions of Myosin Light Chain-2 (MYL2) in Cardiac Muscle and Disease.
Gene 569:14-20 PMID: 26074085 (erratum in: Gene 571:151) § co-corresponding authors.
R.C. Lyon, F. Zanella, J.H. Omens and F. Sheikh (2015) Mechanotransduction in Cardiac Hypertrophy and Failure.
Circ Res 116:1462-1476. PMID: 25858069
F. Sheikh and A. Zanesco (2015) Women in science. Life Sci 125:1. PMID: 25749606
J. Pellman and F. Sheikh (2015) A new mechanism links preamyloid oligomer formation in the myocyte stress
response associated with atrial fibrillation. J Mol Cell Cardiol 80:110-113. PMID: 25541246
J. Pellman and F. Sheikh (2015) Atrial Fibrillation: Mechanisms, Therapeutics and New Directions. Compr Physiol
5:649-665. PMID: 25880508
G. Mastrototaro, X. Liang, X. Li, P. Carullo, Y. Gu, N.D. Dalton, K.L. Peterson, F. Sheikh, J. Chen and M.L. Bang
(2015) Nebulette knockout mice have normal cardiac function but show Z line widening and upregulation of cardiac stress markers. Cardiovasc Res 107:216-225. PMID: 25987543
K.C. Hribar, D. Finlay, X. Ma, X. Qu, M.G. Ondeck, P.H. Chung, F. Zanella, A.J. Engler, F. Sheikh, K. Vuori and S.C.
Chen (2015) Nonlinear 3D projection printing of concave hydrogel microstructures for long-term multicellular spheroid and embryoid body culture. Lab Chip 15: 2412-2418. PMID: 25900329
V. Mezzano, J. Pellman and F. Sheikh (2014) Cell Junctions In the Specialized Conduction System of the Heart. Cell Commun Adhes 21:149-159. PMID: 24738884
F. Sheikh§, R.C. Lyon and J. Chen§ (2014) Getting the Skinny on Thick Filament Regulation in Cardiac Muscle Biology and Disease. Trends Cardiovasc Med 24: 133-141. PMID: 23968570 §co-corresponding authors (Journal Cover)
R.C. Lyon*, V. Mezzano*, A. Wright, E. Pfeiffer, J. Chuang, K. Banares, A. Castaneda, K. Ouyang, L. Cui, Y. Gu, S. Evans, J. Omens, K.L. Peterson, A. McCulloch and F. Sheikh (2014) Connexin Defects Underlie Arrhythmogenic Right Ventricular Cardiomyopathy In a Novel Mouse Model. Hum Mol Genet 23: 1134-1150. PMID: 24108106 *co-first authorship
F. Zanella, R.C. Lyon and F. Sheikh (2014) Modeling Heart Disease in a Dish: From Somatic Cells to Disease-Relevant Cardiomyocytes. Trends Cardiovasc Med 24: 32-44. PMID: 24054750
A.A Domenighetti, P.H. Chu, T. Wu, F. Sheikh, D.S. Gokhin, L.T. Guo, Z. Cui, A.K. Peter, D.C. Christodoulou, M.G. Parfenov, J.M. Gorham, D.Y. Li, I. Banerjee, X. Lai, F.A. Witzmann, C.E. Seidman, J.G. Seidman, A.V. Gomes, G.D. Shelton, R.L. Lieber and J. Chen (2014) Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice. Hum Mol Genet 23: 209-225. PMID: 23975679
C. Lin, X. Guo, S. Lange, J. Liu, K. Ouyang, X. Yin, L. Jiang, Y. Cai, Y. Mu, F. Sheikh, S. Ye, J. Chen, Y. Ke and H. Cheng (2013) Cypher/ZASP is a novel A kinase anchoring protein. J Biol Chem 288: 29403-29413. PMID: 23996002
R. Linke, A. Leichtle, F. Sheikh, C. Schmidt, H. Frenzel, H. Graefe, B. Wollenberg and J.E. Meyer (2013) Assessment of skills using a virtual reality temporal bone surgery simulator. Acta Otorhinolaryngol Ital 33: 273-281. PMID: 24043916
N. Cooley, K. Ouyang, J.R. McMullen, H. Kiriazis, F. Sheikh, W. Wu, Y. Mu, X.J. Du, J. Chen and E.A. Woodcock (2013) No contribution of IP3-R(2) to Disease Phenotype in Models of Dilated Cardiomyopathy or Pressure Overload Hypertrophy. Circ Heart Fail 6: 318-325. PMID: 23258573
N. Rao, S. Evans, D. Stewart, K.H. Spencer, F. Sheikh, E.E. Hui and K.L. Christman (2013) Fibroblasts influence
muscle progenitor differentiation and alignment in contact independent and dependent manners in organized co-culture devices. Biomed Microdevices 15: 161-169. PMID: 22983793
R.C. Lyon*, S. Lange* and F. Sheikh (2013) Breaking down protein degradation mechanisms in cardiac muscle:
Therapeutic outlooks for disease. Trends Mol Med 19: 239-249. PMID: 23453282 *co-first authorship
A. Raskin*, S. Lange*, K. Banares, R.C. Lyon, A. Zieseniss, L. Lee, H. Granzier, C.C. Gregario, A.D. McCulloch, J.H. Omens and F. Sheikh (2012) A Novel Mechanism Involving Four and a Half LIM Domain Protein-1 and Extracellular Signal Regulated Kinase-2 Mediates Titin Phosphorylation and Mechanics. J Biol Chem 287: 29273-29284. PMID: 22778266 *co-first authorship (Journal Cover)
J.A. DeQuach, J.E. Lin, C. Cam, D. Hu, M.A. Salvatore, F. Sheikh and K.L. Christman (2012) Injectable skeletal
muscle matrix hydrogel promotes neovascularization and muscle cell infiltration in a hindlimb ischemia model. Eur Cell Mater 5: 400-412. PMID: 22665162
F. Sheikh*§, K. Ouyang*, S. Campbell*, R.C. Lyon, J. Chuang, D. Fitzsimons, J. Tangney, C.G. Hidalgo, C.S. Chung, H. Cheng, N.D. Dalton, Y. Gu, H. Kasahara, M. Ghassemian, J.H. Omens, K.L. Peterson, H.L. Granzier, R.L. Moss, A.D. McCulloch§ and J. Chen§ (2012) Mouse and computational models link MLC2v dephosphorylation to altered myosin kinetics in early cardiac disease. J Clin Invest 122:1209-1221. PMID: 22426213 *co-first authorship, §co-corresponding authors (received badge of recognition by Faculty 1000; http://f1000.com/prime/717963301)
V. Mezzano and F. Sheikh (2012) Cell-Cell Junction Remodeling in the Heart: Possible Role in Cardiac Conduction
System Function and Arrhythmias? Life Sci 90: 313-321. PMID: 22227473
H. Cheng, M. Zheng, A.K. Peter, K. Kimura, X. Li, K. Ouyang, T. Shen, L. Cui, D. Frank, N.D. Dalton, Y. Gu, N. Frey, K.L. Peterson, S.M. Evans, K.U. Knowlton, F. Sheikh and J. Chen (2011) Selective deletion of long but not short Cypher Isoforms Leads to Late Onset Dilated Cardiomyopathy. Hum Mol Genet 20: 1751-1762. PMID: 21303826
J.A. DeQuach, V. Mezzano, A. Miglani, S. Lange, G.M. Keller, F. Sheikh and K.L. Christman (2010) Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture. PLoS One 27:e13039. PMID:20885963
S.Y. Lu, Y. Jin, X. Li, P. Sheppard, M.E. Bock, F. Sheikh, M.L. Duckworth and P.A. Cattini (2010) Embryonic survival
and severity of cardiac and craniofacial defects are affected by genetic background in FGF-16 null mice. DNA Cell Biol 29: 407-415. PMID: 20618076
T.S. Seeger, D. Frank, C. Rohr, R. Will, S. Just, C. Grund, R. Lyon, M. Ludde, M. Koegl, F. Sheikh, W. Rottbauer,
W.W. Franke, H.A. Katus, E.N. Olson and N. Frey (2010) Myozap, a novel intercalated disc protein, activates SRF
dependent signaling and is required to maintain cardiac function in vivo. Circ Res 106: 880-890. PMID: 20093627
J. Pellman, R.C. Lyon and F. Sheikh (2010) Extracellular matrix remodeling in atrial fibrosis: Mechanisms and
implications in atrial fibrillation. J Mol Cell Cardiol 48:461-467. PMID: 19751740
F. Sheikh, R.S. Ross and J. Chen (2009) The Cell-Cell Connection to Cardiac Disease. Trends Cardiovasc Med 19: 182-190. PMID: 20211433
F. Princen, E. Bard, F. Sheikh, S.S. Zhang, J. Wang, W.M. Zago, D. Wu, R. Diaz Trelles, B. Bailly-Maitre, C.R. Kahn, Y. Chen, J.C. Reed, G.G. Tong, M. Mercola, J. Chen and G.S. Feng. (2009) Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance and premature death. Mol Cell Biol 29: 378-388. PMID: 19001090
F. Sheikh, A. Raskin, P.H. Chu, S. Lange, A.A. Domenighetti, M. Zheng, X. Liang, T. Zhang, T. Yajima, Y. Gu, N.D. Dalton, S.K. Mahata, G.W. Dorn II, J. Heller-Brown, K.L. Peterson, J.H. Omens, A.D. McCulloch and J. Chen. (2008) An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest 118: 3870-3880. PMID: 19033658
S.Y. Lu, F. Sheikh, P.C. Sheppard, A. Fresnoza, M.L. Duckworth, K.A. Detillieux, and P.A. Cattini. (2008) FGF-16 is required for embryonic heart development. Biochem Biophys Res Comm 373: 270-274. PMID: 18565327
F. Sheikh, M.L. Bang, S. Lange and J. Chen. (2007) “Z”eroing in on the Role of Cypher in Striated Muscle Function, Signaling and Human Disease. Trends Cardiovasc Med 17: 258-262. PMID: 18021935
F. Sheikh and J. Chen. (2007) Mouse models for cardiomyopathy research. Prog Pediatric Cardiol 24: 25-32. doi:10.1016/j.ppedcard.2007.08.006
J.P. Gawaziuk, X. Ma, F. Sheikh, Z.Q. Cheng, P.A. Cattini and N.L.Stephens. (2007) TGF-beta as differentiating factor for cultured smooth muscle cells. Eur Respir J 30: 643-652. PMID: 17596270
F. Sheikh, Y. Chen, X. Liang, A. Hirschy, A.E. Stenbit, Y. Gu, N.D. Dalton, T. Yajima, Y. Lu, K.U. Knowlton, K.L. Peterson, J.C. Perriard and J. Chen (2006) alpha-E catenin inactivation disrupts the cardiomyocyte adherens junction resulting in cardiomyopathy and susceptibility to wall rupture. Circulation 114:1046-1055. PMID: 16923756
X. Li, A.V. Zima, F. Sheikh, L.A. Blatter and J. Chen (2005) Endothelin-1-induced arrhythmogenic Ca2+ signaling is abolished in atrial myocytes of inositol-1,4,5-triphosphate (IP3)-receptor type 2- deficient mice. Circ Res 96: 1274-1281. PMID: 15933266
E. Kardami, Z.S. Jiang, S.K. Jimenez, C.J. Hirst, F. Sheikh, P. Zahradka, and P.A. Cattini. (2004) Fibroblast Growth Factor-2 isoforms and cardiac hypertrophy. Cardiovasc Res 82:1044-1052. PMID: 15276471
F. Sheikh, C.J. Hirst, Y. Jin, M.E. Bock, R. R. Fandrich, B.E. Nickel, B.W. Doble, E. Kardami and P.A. Cattini. (2004) Inhibition of TGFbeta signaling potentiates the FGF-induced stimulation of cardiomyocyte DNA synthesis. Cardiovasc Res 64: 516-525. PMID: 15537505
S.K. Jimenez, F. Sheikh, Y. Jin, K.A. Detillieux, J. Dhaliwal, E. Kardami, and P.A. Cattini (2004) Transcriptional regulation of FGF-2 gene expression in cardiac myocytes. Cardiovasc Res 62: 548-557. PMID: 15158147
K.A. Detillieux, F. Sheikh, E. Kardami and P.A. Cattini. (2003) Biological Activities of Fibroblast Growth Factor-2 in the Adult myocardium. Cardiovasc Res 57:8-19. PMID: 12504809
C. Huang, F. Sheikh, M. Hollander, C. Cai, D. Becker, P-H Chu, S. Evans and J. Chen (2003) Embryonic atrial function is essential for mouse embryogenesis, cardiogenesis and angiogenesis. Development 130: 6111-6119. PMID: 14573518
C. Huang, Q. Zhou, P. Liang, M.S. Hollander, F. Sheikh, X. Li, M. Greaser, G.D. Shelton, S. Evans and J. Chen. (2003) Characterization and in vivo functional analysis of splice variants of cypher. J Biol Chem 278:7360-7365. PMID: 12499364
J.T.A. Meij, F. Sheikh, P.W. Nickerson, E. Kardami and P.A. Cattini (2002) Exacerbation of myocardial injury in transgenic mice overexpressing fibroblast growth factor-2 is T cell-dependent. Am J Physiol Heart Circ Physiol 282: H547-H555. PMID: 11788402
F. Sheikh, D.P. Sontag, E. Kardami and P.A. Cattini (2001) Overexpression of FGF-2 increases cardiac myocyte viabililty after injury in isolated mouse hearts. Am J Physiol Heart Circ Physiol 280:H1039-H1050. PMID: 11179045
Y. Jin, F. Sheikh, K.A. Detillieux and P.A. Cattini (2000) Role for early growth response-1 protein in alpha (1)-adrenergic stimulation of fibroblast growth factor-2 promoter activity in cardiac myocytes. Mol Pharmacol 57:984-990. PMID: 10779383
F. Sheikh, R.R. Fandrich, E. Kardami and P.A. Cattini (1999) Overexpression of long or short FGFR-1 results in FGF-2 mediated proliferation in neonatal cardiac myocyte cultures. Cardiovasc Res 42:696-705. PMID: 10533610
P.A. Cattini, Y. Jin and F. Sheikh. (1998) Detection of 28S RNA with the FGF-2 cDNA at high stringency through related G/C-rich sequences. Mol Cell Biochem 189:33-39. PMID: 9879651
F. Sheikh, Y. Jin, K.B.S. Pasumarthi, E. Kardami and P.A. Cattini (1997) Expression of fibroblast growth factor receptor-1 in rat heart H9c2 myoblasts increases cell proliferation. Mol Cell Biochem 176:89-97. PMID: 9406149